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KMID : 1038820210240020207
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Pediatric Gastroenterology, Hepatology & Nutrition
2021 Volume.24 No. 2 p.207 ~ p.217
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Seasonal Changes in Vitamin D Levels of Healthy Children in Mid-Latitude, Asian Urban Area
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Won Jong-Woo
Jung Seong-Kwan
Jung In-Ah
Lee Yoon
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Abstract
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Purpose: This study aimed to investigate the seasonal changes in vitamin D levels in a healthy pediatric population living in mid-latitude East Asian urban areas.
Methods: A pediatric population was selected from single secondary hospital visitors. Clinical data and serum vitamin D levels were collected retrospectively. Statistical analyses were performed based on the month of the blood sampling date, subject age, and vitamin D supplementation history. The data were categorized into three subgroups based on serum vitamin D levels?adequate (≥30 ng/mL), insufficient (20?29 ng/mL), and deficient (<20 ng/mL).
Results: Of the 481 patients, 172 had vitamin D supplementation history. More than 70% of the total study population had inadequate vitamin D levels (<30 ng/mL). The non-supplemented group and the supplemented group showed significantly uneven monthly distribution of the adequate, insufficient, and deficient subgroups. Only the non-supplemented group showed significantly different average vitamin D levels in the summer months compared to the winter months. In the non-supplemented group, vitamin D levels were the lowest in March, the highest in August and September. Significant relevance was noted between vitamin D supplementation status and vitamin D serum level in February and March. There was no significant difference between different age groups in terms of the distribution of vitamin D levels.
Conclusion: Currently-widespread vitamin D replacement methods seem to have some effect on increasing the overall serum vitamin D levels, specifically during late winter when natural serum vitamin D levels plunge. However, they are unable to fully compensate the seasonal fluctuation.
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KEYWORD
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Vitamin D, Calcitriol, Vitamin D deficiency, Seasons, Infant, Child
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